Table 8.
i‐TTR, Time in Other INR Ranges, and INR Test Results and Frequency by Region
| Parameter | Region | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Statistic | Total | East Asia | India | EasternEurope | Western Europe/similar | South Africa | Latin America | Canada/United States | |
| i‐TTR | |||||||||
| i‐TTR (INR 2.0 to 3.0, %) | N (patients) | 6983 | 727 | 130 | 2663 | 1088 | 124 | 924 | 1327 |
| Mean±SD | 55.2±21.27 | 50.4±21.42 | 35.9±23.34 | 49.7±21.16 | 63.2±18.48 | 54.8±22.011 | 55.2±20.00 | 64.1±18.23 | |
| (25th, 75th percentile) | (43.0, 70.6) | (37.6, 64.8) | (18.6, 50.7) | (36.8, 64.8) | (53.7, 75.9) | (42.9, 70.6) | (44.5, 69.3) | (54.8, 77.0) | |
| Time above TR (INR >3.0, %) | N | 6983 | 727 | 130 | 2663 | 1088 | 124 | 924 | 1327 |
| Mean±SD | 15.7±13.13 | 12.6±12.83 | 20.0±21.34 | 15.1±12.61 | 16.5±13.20 | 21.3±18.10 | 17.4±12.95 | 16.0±12.28 | |
| (25th, 75th percentile) | (7.0, 21.5) | (3.7, 17.0) | (6.1, 25.5) | (6.2, 21.2) | (7.4, 22.7) | (8.7, 28.3) | (9.0, 23.5) | (8.3, 21.1) | |
| Time below TR (INR <2.0, %) | N | 6983 | 727 | 130 | 2663 | 1088 | 124 | 924 | 1327 |
| Mean±SD | 29.1±21.94 | 37.1±23.00 | 44.1±25.87 | 35.2±22.78 | 20.2±17.88 | 23.9±23.25 | 27.4±20.01 | 19.9±16.16 | |
| (25th, 75th percentile) | (13.6, 38.6) | (20.6, 51.0) | (25.2, 61.0) | (19.2, 46.3) | (8.7, 26.2) | (7.3, 32.9) | (14.2, 34.1) | (9.1, 26.7) | |
| Time dangerously out of range—low (INR <1.7) | N | 6983 | 727 | 130 | 2663 | 1088 | 124 | 924 | 1327 |
| Mean±SD | 14.8±19.10 | 18.8±19.92 | 30.9±25.73 | 19.7±21.58 | 8.0±13.19 | 11.9±18.61 | 13.8±17.77 | 7.7±11.74 | |
| (25th, 75th percentile) | (2.7, 18.7) | (5.6, 27.0) | (13.6, 48.0) | (5.2, 26.1) | (1.1, 9.5) | (1.1, 14.2) | (3.2, 15.9) | (1.2, 9.7) | |
| Time in INR range of 1.8 to 3.5 | N | 6983 | 727 | 130 | 2663 | 1088 | 124 | 924 | 1327 |
| Mean±SD | 74.5±21.75 | 69.9±22.37 | 51.8±27.30 | 68.8±22.90 | 82.7±17.19 | 75.6±23.62 | 74.8±20.36 | 83.6±15.64 | |
| (25th, 75th percentile) | (65.9, 89.9) | (59.2, 85.9) | (33.1, 72.2) | (58.6, 85.7) | (77.1, 94.1) | (69.9, 90.8) | (67.8, 88.4) | (78.2, 93.8) | |
| INR tests (multiple observations/patient) | N (tests) | 181 640 | 17 218 | 2415 | 64 644 | 30 439 | 3131 | 22 134 | 41 659 |
| Average INR | |||||||||
| Mean±SD | 2.4±0.87 | 2.3±0.83 | 2.4±1.21 | 2.4±0.93 | 2.5±0.80 | 2.5±0.86 | 2.4±0.92 | 2.5±0.78 | |
| Median | 2.3 | 2.2 | 2.1 | 2.2 | 2.4 | 2.4 | 2.3 | 2.4 | |
| (25th, 75th percentile) | (1.8, 2.8) | (1.7, 2.7) | (1.5, 2.8) | (1.7, 2.8) | (2.0, 2.9) | (1.9, 2.9) | (1.8, 2.8) | (2.0, 2.9) | |
| Average No. of tests/patient | Mean±SD | 26±13.3 | 24±10.8 | 19±11.5 | 24±11.6 | 28±13.9 | 25±10.9 | 24±10.6 | 31±17.0 |
| (25th, 75th percentile) | (18, 34) | (17, 32) | (8, 27) | (17, 32) | (19, 37) | (19, 33) | (17, 31) | (19, 43) | |
| Average No. of days between INR measurements | N | 6983 | 727 | 130 | 2663 | 1088 | 124 | 924 | 1327 |
| Mean±SD | 21±5.1 | 23±4.7 | 22±5.6 | 23±5.0 | 20±5.3 | 21±4.8 | 22±4.3 | 19±4.8 | |
| (25th, 75th percentile) | (19, 25) | (22, 26) | (20, 26) | (21, 26) | (16, 24) | (19, 24) | (20, 25) | (17, 23) | |
i‐TTR indicates individual patient‐level time in therapeutic range; INR, international normalized ratio.