Table 1.
Baseline Characteristics of Subjects Who Died, Had a Nonfatal ACS, or Did Not Have an Event Over the 16 Weeks of the Study (P Value From Kruskall–Wallis)
| Death (n=127) | Nonfatal ACS (n=348) | No Event (n=2450) | P Value | |
|---|---|---|---|---|
| Age, mean (SD) | 75 (10) | 68 (12) | 65 (12) | <0.001 |
| Male (%) | 81 (64) | 232 (67) | 1591 (65) | 0.81 |
| Past MI (%) | 56 (44) | 114 (33) | 558 (23) | <0.001 |
| Prior coronary revascularization | 20 (16) | 43 (12) | 238 (10) | 0.04 |
| Hypertension (%) | 82 (65) | 184 (53) | 1326 (54) | 0.058 |
| Current smoker (%) | 14 (11) | 81 (23) | 723 (30) | <0.001 |
| Diabetes (%) | 44 (35) | 91 (26) | 530 (22) | <0.001 |
| Body mass index (kg/m2), mean (SD) | 26.9 (8.5) | 27.4 (4.4) | 27.6 (5.2) | 0.052 |
| Admission to randomization (h), mean (SD) | 68 (45) | 63 (23) | 63 (23) | 0.45 |
| LVEF (%), median (25%, 75%)* | 45 (33, 55) | 50 (42, 61) | 56 (47, 65) | <0.001 |
| Total cholesterol (mg/dL), mean (SD) | 200 (48) | 204 (41) | 206 (37) | 0.12 |
| HDL (mg/dL), mean (SD) | 45 (13) | 45 (11) | 47 (13) | 0.002 |
| LDL (mg/dL), mean (SD) | 122 (40) | 123 (34) | 124 (33) | 0.61 |
| Triglycerides (mg/dL), mean (SD) | 166 (69) | 186 (83) | 183 (92) | 0.09 |
| Troponin I, ng/mL (%) | 64 (50) | 140 (40) | 1042 (43) | 0.10 |
| CRP (mg/L), median (25%, 75%) | 20.1 (6.0, 52.9) | 10.2 (4.5, 33.1) | 10.2 (4.2, 35.0) | 0.005 |
| IL‐6 (pg/mL), median (25%, 75%) | 10.8 (5.5, 20.8) | 7.1 (3.7, 14.1) | 6.7 (3.7, 14.6) | <0.001 |
| SAA (mg/dL), median (25%, 75%) | 2.5 (0.7, 19.7) | 1.4 (0.5, 8.6) | 1.6 (0.6, 8.2) | 0.02 |
| VCAM (ng/L), median (25%, 75%) | 959 (674, 1231) | 870 (656, 1069) | 808 (619, 1020) | <0.001 |
| ICAM (ng/L), median (25%, 75%) | 307 (259, 366) | 302 (263, 366) | 299 (252, 358) | 0.17 |
| P‐Selectin (ng/L), median (25%, 75%) | 65 (46, 96) | 59 (42, 90) | 59 (41, 93) | 0.56 |
| E‐Selectin (ng/L) median (25%, 75%) | 47 (34, 63) | 47 (33, 62) | 48 (35, 62) | 0.63 |
| tPA (ng/L), median (25%, 75%) | 15.1 (10.7, 24.3) | 14.6 (9.6, 21.5) | 13.5 (8.5, 20.3) | 0.003 |
ACS indicates acute coronary syndrome; MI, myocardial infarction; LVEF, left ventricular ejection fraction; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; CRP, C‐reactive protein; IL‐6, interleukin‐6; SAA, serum amyloid A; VCAM, vascular cell adhesion molecule; ICAM, intercellular adhesion molecule; tPA, tissue plasminogen activator antigen.
*
LVEF measured in 910 subjects.