Table 2.
Hazard Ratios for Quartiles of Biomarkers at Baseline and Death and Recurrent Nonfatal ACS of Myocardial Infarction or Unstable Angina
| Quartile 1, Reference | Quartile 2, HR (95% CI) | Quartile 3, HR (95% CI) | Quartile 4, HR (95% CI) | Test‐of‐Trend | |
|---|---|---|---|---|---|
| CRP | |||||
| Death | 1.00 | 0.97 (0.54 to 1.75) | 1.08 (0.61 to 1.91) | 1.69 (0.99 to 2.90) | 0.034 |
| Nonfatal ACS | 1.00 | 1.06 (0.78 to 1.44) | 1.09 (0.80 to 1.49) | 0.98 (0.70 to 1.36) | 0.941 |
| IL‐6 | |||||
| Death | 1.00 | 1.05 (0.56 to 1.98) | 1.29 (0.71 to 2.35) | 1.61 (0.90 to 2.90) | 0.060 |
| Nonfatal ACS | 1.00 | 0.82 (0.60 to 1.13) | 0.94 (0.69 to 1.27) | 0.84 (0.61 to 1.16) | 0.439 |
| SAA | |||||
| Death | 1.00 | 0.66 (0.36 to 1.21) | 1.14 (0.66 to 1.97) | 1.41 (0.82 to 2.43) | 0.045 |
| Nonfatal ACS | 1.00 | 0.87 (0.65 to 1.18) | 0.85 (0.62 to 1.16) | 0.96 (0.70 to 1.33) | 0.783 |
| ICAM | |||||
| Death | 1.00 | 1.21 (0.69 to 2.10) | 1.26 (0.73 to 2.19) | 1.53 (0.89 to 2.62) | 0.131 |
| Nonfatal ACS | 1.00 | 1.41 (1.03 to 1.94) | 1.18 (0.84 to 1.65) | 1.48 (1.07 to 2.05) | 0.064 |
| VCAM | |||||
| Death | 1.00 | 0.83 (0.45 to 1.52) | 0.74 (0.40 to 1.34) | 1.12 (0.65 to 1.94) | 0.484 |
| Nonfatal ACS | 1.00 | 1.09 (0.79 to 1.51) | 1.11 (0.80 to 1.54) | 1.12 (0.81 to 1.55) | 0.531 |
| E‐selectin | |||||
| Death | 1.00 | 1.01 (0.59 to 1.73) | 0.92 (0.52 to 1.62) | 1.26 (0.74 to 2.13) | 0.486 |
| Nonfatal ACS | 1.00 | 0.77 (0.56 to 1.06) | 0.85 (0.62 to 1.16) | 0.87 (0.64 to 1.20) | 0.489 |
| P‐selectin | |||||
| Death | 1.00 | 1.40 (0.79 to 2.45) | 1.69 (0.98 to 2.93) | 1.71 (0.99 to 2.95) | 0.043 |
| Nonfatal ACS | 1.00 | 1.30 (0.95 to 1.77) | 1.29 (0.94 to 1.77) | 1.13 (0.82 to 1.56) | 0.508 |
| tPA | |||||
| Death | 1.00 | 1.17 (0.67 to 2.03) | 0.83 (0.46 to 1.48) | 1.27 (0.75 to 2.16) | 0.574 |
| Nonfatal ACS | 1.00 | 1.01 (0.73 to 1.41) | 1.16 (0.84 to 1.59) | 1.20 (0.88 to 1.65) | 0.178 |
Hazard ratios are adjusted by treatment group, age, past myocardial infarction, prior coronary revascularization, diabetes mellitus, current smoking, HDL cholesterol, and positive troponin. ACS indicates acute coronary syndrome; CRP, C‐reactive protein; IL‐6, interleukin‐6; SAA, serum amyloid A; ICAM, intercellular adhesion molecule; VCAM, vascular cell adhesion molecule; tPA, tissue plasminogen activator antigen.