Table 4.
Correlation Between Cholesterol Homeostasis Markers and CVD Risk Factors*
Variable | Women | Men | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Age | BMI | LDL‐C | HDL‐C | Non–HDL‐C | TG* | Age | BMI | LDL‐C | HDL‐C | Non–HDL‐C | TG | |
Cholesterol synthesis markers* | ||||||||||||
Squalene | −0.14* | −0.06* | −0.13* | 0.02 | −0.12* | −0.04 | −0.16* | 0.03 | −0.10* | −0.09* | −0.04 | 0.07* |
Desmosterol | 0.11* | 0.06* | −0.07* | −0.03 | −0.07* | −0.03 | 0.19* | 0.06 | −0.17* | 0.02 | −0.18* | −0.08* |
Lathosterol | 0.07* | 0.08* | −0.08* | 0.02 | −0.08* | −0.04 | 0.11* | 0.02 | −0.10* | −0.05 | −0.06* | 0.07* |
Cholesterol absorption markers* | ||||||||||||
Campesterol | −0.12* | −0.23* | −0.01 | 0.14* | −0.09* | −0.26* | −0.21* | −0.15* | 0.02 | 0.10* | −0.04 | −0.19* |
Sitosterol | −0.12* | −0.30* | −0.03 | 0.14* | −0.12* | −0.31* | −0.17* | −0.20* | 0.03 | 0.11* | −0.04 | −0.19* |
Cholestanol | −0.02 | 0.03 | −0.31* | −0.04 | −0.30* | −0.10* | −0.01 | 0.01 | −0.27* | −0.07* | −0.28* | −0.08* |
Cholesterol synthesis:absorption ratio* | ||||||||||||
Lathosterol:campesterol | 0.13* | 0.22* | −0.04 | −0.09* | 0.01 | 0.16* | 0.22* | 0.12* | −0.08* | −0.10* | −0.01 | 0.18* |
Lathosterol:sitosterol | 0.13* | 0.26* | −0.02 | −0.08* | 0.04 | 0.19* | 0.19* | 0.15* | −0.09* | −0.11* | −0.01 | 0.18* |
Lathosterol:cholestanol | 0.07* | 0.04 | 0.17* | 0.04 | 0.15* | 0.03 | 0.09* | 0.003 | 0.11* | 0.01 | 0.14* | 0.11* |
CVD indicates cardiovascular disease; BMI, body mass index; LDL‐C, LDL cholesterol; HDL‐C, HDL cholesterol; TG, triglycerides.
Pearson product moment correlation coefficient.
Triglycerides and cholesterol synthesis and absorption markers and ratios were log‐transformed during analysis to correct for their skewed distributions.
‡P<0.05; §P<0.01; ¶P<0.001.