Figure 2.

RC defect-augmented loss in cell viability during H₂O₂ stress as measured by the MTT assay. (a, b) Dose-dependent cytotoxic effect induced by H₂O₂ exposure in control (filled columns) and ρ ⁰ RBA1 astrocytes (empty columns); (a) time point for H₂O₂ exposure: 10 min and (b) 30 min. There were no statistically significant differences between the two groups in the cell viability at different concentration for 10 minutes (P > 0.05) (a). 20 mM H₂O₂ caused a statistically significant loss in cell viability in ρ ⁰ astrocytes for 30 min when compared to control cells (P < 0.001) (b). Data were expressed as mean values ± SE of four separate experiments. *P < 0.001.