Table 1.
Iron-Binding Site Observation for Transferrin Protein among Taxa.
| Members | Organisms | Active Sites (Iron-Binding Residues) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| N-Lobe |
C-Lobe |
||||||||
| D64 | Y244 | Y356 | H430 | D610 | Y659 | Y783 | H863 | ||
| Outgroup | Ciona intestinalis | / | / | / | / | / | / | / | / |
| Otolith matrix protein-1 | Danio rerio1 | — | — | — | — | Y | / | E | N |
| Oncorhynchus mykiss | — | — | — | — | F | / | E | N | |
| Gadus morhua1 | — | — | — | — | F | / | E | P | |
| Oryzias latipes1 | — | — | — | — | F | / | E | N | |
| Gasterosteus aculeatus1 | — | — | — | — | F | / | E | N | |
| Tetraodon nigroviridis1 | — | — | — | — | S | / | E | N | |
| Takifugu rubripes1 | — | — | — | — | P | / | E | N | |
| Melanotransferrin | Oryctolagus cuniculus1 | / | / | / | / | N | / | D | / |
| Homo sapiens1 | / | / | / | / | S | / | / | / | |
| Mus musculus1 | / | / | / | / | R | / | / | / | |
| Gallus gallus1 | / | / | / | R | G | / | / | Q | |
| Ornithorhynchus anatinus | / | / | / | / | G | / | / | Q | |
| Anolis carolinensis1 | — | — | — | / | S | / | / | R | |
| Xenopus tropicalis1 | / | / | / | / | / | / | / | / | |
| Gad. morhua2 | / | / | / | R | / | / | / | / | |
| O. latipes2 | / | / | / | R | / | / | / | / | |
| G. aculeatus2 | / | / | / | R | / | / | / | / | |
| T. nigroviridis2 | / | / | / | R | / | / | / | / | |
| Tak. rubripes2 | / | / | / | R | / | / | / | / | |
| Novel transferrin | D. rerio2 | / | I | F | G | / | V | N | N |
| O. latipes3 | / | V | F | G | / | L | N | N | |
| G. aculeatus3 | / | I | F | G | / | V | N | N | |
| Tak. rubripes3 | / | H | F | G | / | V | N | N | |
| T. nigroviridis3 | / | L | F | A | / | V | N | N | |
| Gad. morhua3 | / | I | / | G | / | V | N | N | |
| X. tropicalis2 | / | V | F | K | / | L | N | N | |
| A. carolinensis2 | — | — | F | R | / | T | N | G | |
| Gal. gallus2 | / | V | F | R | / | V | N | S | |
| Serotransferrin (Fish) | Paralichthys olivaceus | / | / | / | / | / | / | / | / |
| Gad. morhua3 | / | / | / | / | / | / | / | / | |
| G. aculeatus4 | / | / | / | / | / | / | / | / | |
| O. latipes4 | / | / | / | / | / | / | / | / | |
| Lates calcarifer | / | / | / | / | / | / | / | / | |
| Tak. rubripes4 | / | / | / | / | / | / | / | / | |
| O. kisutch | / | / | / | / | / | / | / | / | |
| Salmo salar1 | / | / | / | / | / | / | / | / | |
| S. salar2 | / | / | / | / | / | / | / | / | |
| Serotransferrin (Amphibian) | X. laevis | / | / | / | / | / | / | / | / |
| Saxiphilin (Amphibians) | Rana catesbeiana | / | H | / | G | E | L | N | P |
| Ovotransferrin-like (nonavian sauropsids) | A. carolinensis3 | — | / | / | / | / | / | / | / |
| Ovotransferrin (Birds) | Gal. gallus3 | / | / | / | / | / | / | / | / |
| Gal. gallus4 | / | / | A | / | / | / | / | / | |
| Lactoferrin (Mammals) | Bos taurus2 | / | / | / | / | / | / | / | / |
| M. musculus4 | / | / | / | / | / | / | / | / | |
| H. sapiens3 | / | / | / | / | / | / | / | / | |
| ICA (Mammals) | M. musculus3 | / | / | / | / | / | / | S | R |
| Sus scrofa | / | / | / | / | / | / | F | / | |
| Serotransferrin (Mammals) | Equus caballus | / | / | / | / | / | / | / | / |
| B. taurus1 | / | / | / | / | / | / | / | / | |
| M. musculus2 | / | / | F | / | / | / | / | / | |
| Ory. cuniculus2 | / | / | / | / | / | / | / | / | |
| H. sapiens2 | / | / | / | / | / | / | / | / | |
Note.— / and — symbols indicate “as in reference” and “missing,” respectively.