Skip to main content
. Author manuscript; available in PMC: 2014 Feb 11.
Published in final edited form as: Cancer Cell. 2013 Feb 11;23(2):186–199. doi: 10.1016/j.ccr.2012.12.020

Figure 6. Correlation between miR-506 and SNAI2, E-cadherin, and VIM expression and prognosis in multiple serous OvCa cohorts.

Figure 6

(A) Representative images of in situ hybridization staining for U6 snRNA (positive control) and miR-506 and immunohistochemical staining for SNAI2, E-cadherin (E-cad), and vimentin (VIM) in low and high miR-506 expression cases. The low and high miR-506 expression was stratified by using average of miR-506 PCR expression as threshold. Scale bar represents 100 μm. (B) Bar charts show the association between miR-506 expression and SNAI2, E-cadherin, and VIM expression. The low and high miR-506 expression is based on average value of miR-506 PCR expression. The x-axes represent miR-506 expression, as measured by in situ hybridization, and SNAI2, E-cadherin (E-cad), and vimentin (VIM) expression, as indicated by immunohistochemical staining. Error bars represent ± SD. * p<0.05 **<0.01. (C) Kaplan-Meier overall survival curves in miR-506 low and high expression OvCa cases. The low and high miR-506 expression is based on average value of miR-506 PCR expression. (D and E) Kaplan-Meier progression free survival curves in miR-506 low and high expression (according to average of miR-506 expression) in 129 Bentink cases (panel D) and 55 Bagnoli cases (panel E). See also Figure S6.