Table 1. The 18 drugs that were found to potentially interact with metabolic reactions and non-metabolic proteins of the gut bacteria (based either on chemical similarity between the drug and the metabolite or sequence similarity of the drug target and a bacterial protein) and for which information on relevant side effects was retrieved from SIDER (in parenthesis is the number of essential reactions).

Drug	ATC-code	DrugBank ID	Metabolic reactions	Non-metabolic targets	Abdominal pain	Colitis	Constipation	Diarrhea	Dyspepsia	Flatulence	Weight gain
Aripiprazole	N05AX12	DB01238	0 (0)	1 (0)	—	0.001	0.02–0.11	0–0.03	0.07–0.09	0.001	—
Clarithromycin	J01FA09	DB01211	0 (0)	1 (1)	0–0.012	—	0–0.004	0–0.023	—	—	—
Cytarabine	L01BC01	DB00987	5 (1)	0 (0)	—	—	0–0.25	—	—	—	—
Doxycycline	A01AB22 J01AA02	DB00254	0 (0)	3 (3)	—	—	—	0.0372	0.023	—	—
Imiquimod	D06BB10	DB00724	1 (0)	0 (0)	0.005–0.0111	—	—	0.01–0.03	0.01–0.028	—	—
Meropenem	J01DH02	DB00760	0 (0)	4 (0)	—	—	—	0.035–0.047	—	—	—
Olanzapine	N05AH03	DB00334	0 (0)	1 (0)	0.001	—	0.03–0.11	0.001–0.19	0.05–0.11	0.001–0.01	0–0.26
Pergolide	N04BC02	DB01186	0 (0)	1 (0)	0.01–0.058	—	0.01–0.106	0.01–0.064	0.01–0.064	0.001	0–0.016
Pyrazinamide	J04AK01	DB00339	1 (0)	0 (0)	—	—	—	0.07–0.11	—	—	—
Quetiapine	N05AH04	DB01224	0 (0)	1 (0)	0.01–0.07	—	0.03–0.1	—	0.01–0.07	0.001	0.01–0.06
Rifabutin	J04AB04	DB00615	1 (1)	0 (0)	0.03–0.04	—	—	0.03	0.01–0.03	0.01–0.02	—
Rifampin	J04AB02	DB01045	1 (1)	0 (0)	—	—	—	0.07–0.11	—	—	—
Rifaximin	A07AA11 D06AX11	DB01220	1 (1)	0 (0)	—	—	0.035–0.038	—	—	0.112–0.197	—
Ropinirole	N04BC04	DB00268	0 (0)	1 (0)	0.001–0.06	0.001	0.01–0.04	0.02–0.03	—	0.001	—
Stavudine	J05AF04	DB00649	7 (2)	0 (0)	—	—	—	0–0.5	—	—	—
Tobramycin	J01GB01 S01AA12	DB00684	0 (0)	2 (2)	0.128–0.237	—	—	0.062–0.103	—	—	—
Trovafloxacin	J01MA13	DB00685	0 (0)	8 (3)	0–0.01	—	—	0.02	—	—	—
Ziprasidone	N05AE04	DB00246	0 (0)	1 (0)	0–0.02	—	0–0.09	0–0.05	0.01–0.08	—	—