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. 2012 Nov 8;24(4):909–916. doi: 10.1093/annonc/mds530

Figure 2.

Figure 2.

(A) Multivariable Cox proportional hazard model for the predictive markers and risk score (RS) calculation. (B) Unsupervised clustering of 99 residual breast cancers (training set). Two potential clusters were defined according the independent predictive markers from the multivariable CoxBoost analysis (Caveolin1, Rab25, and CHK1pS345). (C) Recurrence-free survival by clusters in the training set defined a high and a low risk of the recurrence group. (D) ROC curve of the RS in all residual breast cancers (test set). (E) Unsupervised clustering of 79 HR-positive residual breast cancers (validation set). Two clusters characterized by the independent predictive markers from the multivariable CoxBoost analysis (Caveolin1, RAB25, and CHK1pS345). (F) Recurrence-free survival by clusters in the validation set defined a high and a low risk of the recurrence group.