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. 2013 Jan;3(1):120157. doi: 10.1098/rsob.120157

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© 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — T_REG specialization and plasticity. T_REG cells can co-express T helper cell lineage-defining TFs, such as Tbet and Foxp3 (red, lower right segment), during various infectious or inflammatory scenarios. This specialization appears to fine tune T_REG cells to more effectively regulate the corresponding effector T_H cell. For example Tbet⁺Foxp3⁺ T_REG cells can potently suppress Tbet⁺ T_H1 cells. Thus, the co-expression of various TFs is required to confer the appropriate and necessary regulatory programme. Whether these hybrid ‘specialized’ T_REG cells are intermediate cells in between the T_H to T_REG conversion (indicated by arrows in figure), or a stable population is unclear. GC, germinal centre.