Table 1.
Phenotype and Function of T-Cell Subsets
| T-cell subset | Phenotype |
|---|---|
| Naïve | CD62L+++ CCR7+++ |
| CD27+++ CD28+++ | |
| CD45RA+++ CD45RO− | |
| KLRG-1−CD57− | |
| TCM | CD62L++CCR7++ |
| CD27++CD28++ | |
| CD45RA−CD45RO+++ | |
| KLRG-1−CD57− | |
| TEM | CD62L−CCR7− |
| CD27++CD28− | |
| CD45RA−CD45RO+++ | |
| KLRG-1++CD57− | |
| Teff | CD62L−CCR7− |
| CD27−CD28− | |
| CD45RA−/+CD45RO++ | |
| KLRG-1+++CD57++ | |
| Treg | CD25+++ |
| FOXP3+++ |
The phenotypic expressions or functional attributes are indicated as low (+), intermediate (++), and high (+++).
RA, rheumatoid arthritis; TCM, central memory T cells; TEM, effector memory T cells; Teff, effector T; Treg, regulatory T cell.