Table 2.

T-Cell and Role of Antioxidant Molecules

No.	Antioxidants	Protein name	Antioxidant role in T-cell regulation	Reference
1	GSH	Glutathione	Tregs block GSH redistribution from the nucleus to the cytoplasm in Teff cells	(314)
2	GST	s-S-Transferase	Activator protein-1 induction by GST gene expression alters intracellular oxidative stress	(224)
3	GCLC	Glutamate–cysteine ligase catalytic subunit	Mitogen activation leads to: Upregulated GCLC catalytic subunit Depletion of GSH	(300)
4	GCLM	Glutamate–cysteine ligase, modifier subunit	Mitogen activation leads to increased GCLM catalytic subunit	(300)
5	GLUT1	Glucose transporter 1	Induced upon TCR activation	(274)
6	TRX	Thioredoxin	Overexpression blocks NFκB activation by H2O2. Induces IL-2R expression on T cells	(148)

NFκB, nuclear factor kappa B; TCR, T-cell receptor; Treg, regulatory T cell.