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. 2013 Jan 1;126(1):234–243. doi: 10.1242/jcs.113795

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© 2013. Published by The Company of Biologists Ltd

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Fig. 1. — Chondrocyte-specific deletion of Jab1 in mice leads to severe and generalized lethal chondrodysplasia. (A) Immunostaining reveals strong Jab1 expression in murine E18.5 femur. PC, proliferating chondrocytes; HC, hypertrophic chondrocytes. (B) Whole-mount Jab1^flox/flox; Col2a1-Cre mutant embryos at E18.5. (C) Skeletal preparations with alcian blue staining of cartilage and alizarin red staining of bone show severe and generalized chondrodysplasia in E18.5 Jab1^flox/flox; Col2a1-Cre mutants. MUT, Jab1 cKO mutants; WT, wild-type littermates.