Table 6.
Effects of feeding broccoli extract and various essential oils on relative mRNA expression of various pro- and anti-inflammatory parameters in the liver of DSS-treated rats compared to an untreated control.
Liver | Period | Experimental group compared | ||||
---|---|---|---|---|---|---|
with untreated control rats | ||||||
Gene | DSS | BE | Cuo | To | Ro | |
Phase 1 | — | ↔ | ↔ | ↔ | ↔ | |
NFκB | Phase 2 | ↔ | ↔ | ↔ | ↔ | ↔ |
Phase 3 | ↔ | ↔ | ↔ | ↔ | ↔ | |
Phase 1 | — | ↔ | ↔ | ↔ | ↔ | |
TNFα | Phase 2 | ↔ | ↔ | ↔ | ↔ | ↔ |
Phase 3 | ↑ | ↔ | ↔ | ↔ | ↔ | |
Phase 1 | — | ↔ | ↔ | ↔ | ↔ | |
COX2 | Phase 2 | ↔ | ↔ | ↔ | ↔ | ↔ |
Phase 3 | n.d. | n.d. | n.d. | n.d. | n.d. | |
Phase 1 | — | ↔ | ↔ | ↔ | ↔ | |
IL-1β | Phase 2 | ↔ | ↔ | ↔ | ↔ | ↔ |
Phase 3 | ↔ | ↔ | ↔ | ↓ | ↔ | |
Phase 1 | — | ↓ | ↓ | ↔ | ↓ | |
IL-10 | Phase 2 | ↔ | ↔ | ↔ | ↔ | ↔ |
Phase 3 | ↓ | ↓ | ↓ | ↓ | ↓ | |
Phase 1 | — | ↔ | ↔ | ↔ | ↑ | |
MCP-1 | Phase 2 | ↔ | ↔ | ↔ | ↔ | ↔ |
Phase 3 | ↔ | ↔ | ↔ | ↔ | ↔ | |
Phase 1 | — | ↓ | ↔ | ↔ | ↔ | |
VCAM-1 | Phase 2 | ↔ | ↔ | ↔ | ↔ | ↔ |
Phase 3 | ↔ | ↔ | ↔ | ↔ | ↔ | |
Phase 1 | — | ↔ | ↔ | ↔ | ↔ | |
Cldn3 | Phase 2 | ↔ | ↔ | ↔ | ↔ | ↔ |
Phase 3 | ↔ | ↑ | ↔ | ↔ | ↔ |
Different arrows summarize the effects on gene expression: ↔: no effect, ↑: increase, ↓: decrease, and n.d.: not detectable. Means ± SEM and the results of statistical analysis are presented in the appendix.