Table 1.

Demographics of participants included in the fMRI study. Psychotropic medications included selective serotonin reuptake inhibitors, psychostimulants, and antipsychotic medications. Independent samples t-tests were conducted to determine whether the groups were significantly different on age, intelligence quotient (IQ), the vocabulary and block design scaled scores, and the Social Responsiveness Scale (SRS), a quantitative measure of autistic traits. While age was not significantly different between Simplex Autism and typical cohorts (P = 0.28), IQ was significantly greater for the typical than the Simplex Autism cohort (P = 0.016). SRS was significantly greater for the Simplex Autism than the typical cohort (P < 0.0001). The vocabulary (P = 0.019) but not block design (P = 0.15) subscale score was significantly greater in the typical cohort. One typical subject did not perform the block design subtest, and was not included in the t-test comparison.

	Demographics
	Simplex Autism subjects	Typical subjects
Male/female	13m/3f	13m/3f
Age	11.9 ± 1.89	12.6 ± 1.80
IQ	104.9 ± 12.97	115.7 ± 10.64
Vocabulary scaled score	10.25 ± 3.26	13.00 ± 2.37
Block design scaled score	10.88 ± 3.05	12.23 ± 2.12
SRS	102 ± 21.7	17.8 ± 9.56
Medicated/un-medicated	8/8	0/16