Table 1.
Plasma Concentrations for All Participants, Non-Responders, and Responders
| All Participants | Non-Responders | Responders | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | M | SD | GM | 90% CI | N | M | SD | GM | 90% CI | N | M | SD | GM | 90% CI | |
| Paroxetine | 34 | 34.1 | 29.1 | 23.4 | 17.8–30.8 | 21 | 37.1 | 29.7 | 26.6 | 19.0–37.4 | 13 | 29.1 | 28.4 | 19.0 | 11.6–31.2 |
| Citalopram | 27 | 50.5 | 37.0 | 36.6 | 26.4–50.9 | 11 | 40.2 | 35.2 | 22.7 | 10.8–47.8 | 16 | 57.6 | 37.6 | 50.9 | 41.6–62.4 |
| Fluoxetine | 64 | 85.8 | 58.2 | 62.0 | 50.3–76.4 | 32 | 81.6 | 68.8 | 48.3 | 32.9–71.0 | 32 | 90.0 | 46.1 | 79.5 | 68.1–92.9 |
| Norfluoxetine | 64 | 96.4 | 44.9 | 79.6 | 67.4–93.9 | 32 | 88.8 | 50..3 | 65.5 | 48.3–88.8 | 32 | 104.0 | 38.1 | 96.6 | 85.5–109.2 |
| Fluoxetine + Norfluoxetine | 64 | 182.2 | 90.7 | 147.8 | 124.3–175.7 | 32 | 170.4 | 108.2 | 119.5 | 86.2–165.6 | 32 | 193.9 | 68.8 | 182.8 | 164.5–203.0 |
| Venlafaxine | 119 | 123.0 | 126.2 | 71.0 | 59.0–85.6 | 54 | 140.3 | 156.2 | 78.5 | 59.5–103.6 | 65 | 108.6 | 93.1 | 65.4 | 50.6–84.4 |
| O-desmethylvenlafaxine | 119 | 200.5 | 125.7 | 139.2 | 117.4–165.2 | 54 | 219.9 | 130.8 | 162.9 | 129.5–205.0 | 65 | 184.4 | 119.8 | 122.2 | 95.2–156.8 |
| Venlafaxine + O-desmethylvenlafaxine | 119 | 323.5 | 195.1 | 231.8 | 197.1–272.7 | 54 | 360.2 | 212.2 | 269.6 | 215.3–337.4 | 65 | 293.0 | 175.6 | 204.5 | 162.0–258.1 |
N=number of cases. M=arithmetic mean. SD=standard deviation. GM= geometric mean. CI=confidence interval. All data included. Zero-levels replaced with 4.0 ng/ml for paroxetine, venlafaxine and o-desmethylvenlafaxine, 1.5 ng/ml for citalopram, and 3.0 ng/ml for fluoxetine and norfluoxetine.