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. 2013 Mar 20;8(3):e59616. doi: 10.1371/journal.pone.0059616

Figure 2. Galectin-3−/− mice display reduced levels of inflammatory mediators in lungs after pulmonary infection with F.n.

Figure 2

The lungs from WT mock infected (WT-M), galectin-3−/− mock infected (Gal-3−/−M), WT F. novicida infected (WT-Inf) or galectin-3−/− F. novicida infected mice (Gal3−/−Inf) were harvested at 3 d.p.i., homogenized with protease inhibitors in PBS and analyzed commercially for rodent multi-analyte profiles (Rules-Based Medicine, Austin, TX). (A), levels of vascular injury markers; (B), levels of inflammatory cytokines; and (C), levels of neutrophil attractant chemokines and activation markers in lung homogenates. Results shown are from 3–4 mice per group from 3 different experiments. CRP; C-reactive protein, MMP-9; matrix metalloproteinase 9, MPO; myeloperoxidase. *p<0.05; **p<0.005.