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. 2013 Mar 20;8(3):e59616. doi: 10.1371/journal.pone.0059616

Figure 6. Galectin-3−/− mice show improved survival during pulmonary F.n. infection.

Figure 6

(A). Fifteen C57Bl/6 WT and 17 galectin-3−/− mice in 3 separate experiments were inoculated intranasally with F. novicida and were monitored for survival daily for 2 weeks. The improved survival of galectin-3−/− mice compared to WT mice was statistically significant, as determined by Kaplan-Meier log-rank analysis (P value*** = 0.0003). (B) Bacterial burdens in lungs harvested from F. novicida infected WT and galectin-3−/− mice at 3 d.p.i. Lungs and liver were harvested from infected mice, homogenized as described in Materials and Methods. Tissue homogenates and blood harvested at the same time, were serially diluted and plated on TSA plates to enumerate bacterial burdens. In this representative of three independent experiments, each group contained three to five mice.