Table 2. Change in body weight and leptin after chronic dietary switches.

	Control	Control-HF	Control-CR	HF-control	HF	HF-CR
Body weight (g)	28.8 (0.7)	33.6 (0.9)	20.5 (0.5)	30.5 (0.9)	35.1 (1.9)	26.2 (0.6)
Delta body weight (g)	−1.9 (0.4)	1.7 (0.4)	−8.0 (0.7)	−4.3 (0.7)	−1.3 (0.6)	−10.6 (1.1)
Leptin (ng/ml)	1.13 (0.16)	6.06 (0.16)	0.29 (0.05)	1.26 (0.25)	7.29 (1.91)	0.37 (0.08)
	Final body-weight (P value)		Delta change in body-weight (P value)		Final plasma leptin (P value)
Control vs . Control-HF	0.0001*		0.0001*		0.01*
Control vs . Control-CR	0.0001*		0.0001*		0.001*
Control-HF vs . Control-CR	0.0001*		0.0001*		0.01*
HF-control vs . HF	0.1		0.07		0.04*
HF-control vs . HF-CR	0.0001*		0.0001*		0.02*
HF vs . HF-CR	0.0001*		0.0001*		0.02*

Control = standard dietary chow maintained, Control-HF = standard dietary chow switch to high-fat diet, Control-CR = standard dietary chow switch to caloric restriction; HF-Control = high-fat diet switch to standard dietary chow, HF = high-fat diet maintained, HF-CR = high-fat diet switch to caloric restriction; data presented as P value (post-hoc ANOVA).