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. 2013 Mar 20;8(3):e59278. doi: 10.1371/journal.pone.0059278

Table 1. Active site residues in Sirutin 2.

NAD Binding Site Adenosine Binding Site Ribose Binding Site Nicotinamide Binding Site
Literature Report N286 E288 R97 A85 Q167 H187 S88 H149 F96 N168 I169 D170
Docking Result
WT-NAD N286 A85 Q167 H187 N168 I169 D170
Q167A-NAD N286 A85 N168 D170
H187A-NAD N286 A85 Q167 N168 I169 D170
WT-Inhibitor Q167 I169
Q167A-Inhbitor A167 H187 I169
H187A-Inhibitor Q167 I169