Table 1. Statistics for all outcome variables used in this study; see Table S1 for means and distribution of samples across groups used in comparisons.

Variable	Circulating Leukocytes (WBC)	Total Immunoglobulin (Tig)	Total Antioxidant Power (TAP)	IL-4
Site Type – all samples	§ U = 1336; p = 0.008; N = 134	€F = 0.984; p = 0.33; n = 66	U = 1877; p<0.001; n = 191	U = 285; p = 0.035; n = 73
Site Location – all samples	‡χ2 = 9.706; p = 0.08; n = 134	F = 8.248; p<0.001; n = 148	χ2 = 23.06; p<0.001; n = 191	χ2 = 9.126; p = 0.058; n = 73
Hibernation Stage – affected Aeolus Cave only	χ2 = 1.541; p = 0.46; n = 94	F = 4.962; p<0.001; n = 54	χ2 = 4.414; p = 0.11; n = 56	χ2 = 3.30; p = 0.22; n = 15
Body Temperature (measurment) – all samples	◊ρ = 0.13; p = 0.13; n = 134	F = 0.03; p = 0.86; n = 148	ρ = 0.074; p = 0.31; n = 191	ρ = -0.19; p = 0.12; n = 73
affected sites	ρ = 0.18; p = 0.08; n = 94	F = 3.33; p = 0.07; n = 114	ρ = 0.07; p = 0.41; n = 147	ρ = -0.25; p = 0.06; n = 59
unaffected sites	ρ = -0.18; 0.91; n = 40	F = 4.962; p = 0.034; n = 34	ρ = 0.03; p = 0.86; n = 44	ρ = -0.14; p = 0.63; n = 14
Body Temperature (categorical) – allsamples	χ2 = 4.708; p = 0.09; n = 134	F = 1.09; p−0.34; n = 148	χ2 = 4.708; p = 0.09; n = 191	χ2 = 5.17; p = 0.08; n = 73
affected sites	χ2 = 3.586; p = 0.022; n = 94	F = 1.78; p = 0.17; n = 114	χ2 = 3.586; p = 0.022; n = 147	χ2 = 4.872; p = 0.09; n = 59
unaffected sites	χ2 = 3.586; p = 0.17; n = 40	F = 3.33; p = 0.049; n = 34	χ2 = 3.586; p = 0.17; n = 44	χ2 = 0.386; p = 0.83; n = 14
Hematocrit – all samples	ρ = 0.039; p = 0.66; n = 196	F = 1.12; p = 0.29; n = 148	ρ = 0.039; p = 0.66; n = 195	ρ = −0.005; p = 0.97; n = 73
affected sites	ρ = 0.031; p = 0.77; n = 93	F = 0.68; p = 0.41; n = 114	ρ = 0.031; p = 0.77; n = 93	ρ = 0.031; p = 0.77; n = 93
unaffected sites	ρ = −0.09; p = 0.58; n = 68	F = 0.548; p = 0.47; n = 34	ρ = −0.09; p = 0.58; n = 70	ρ = −0.09; p = 0.58; n = 70
Visible Symptoms – mid-hibernation only	U = 1013; p = 0.75; n = 92	F = 1.262; p = 0.26; n = 117	U = 1899; p = 0.009; n = 144	U = 287; p = 0.048; n = 59
Body Mass Index – all samples	ρ = −0.08; p = 0.36; n = 133	F = 0.07; p = 0.8; n = 148	ρ = 0.16; p = 0.035; n = 179	ρ = 0.44; p = 0.12; n = 73
affected sites	ρ = 0.09; p = 0.4; n = 92	F = 1.75; p = 0.19; n = 114	ρ = 0.11; p = 0.21; n = 141	ρ = 0.06; p = 0.69; n = 57
unaffected sites	ρ = −0.11; p = 0.5; n = 38	F = 1.713; p = 0.2; n = 34	ρ = 0.08; p = 0.63; n = 43	ρ = 0.44; p = 0.12; n = 14

Key:

^§Mann-Whitney U;

^‡Kruskal-Wallis;

^◊Spearman correlation;

^€Mixed model ANOVA/ANCOVA.