Table 2.

Between-Group Differences in Activation

	Hemisphere	MNI coordinates			Max Z-value	Max p-value1
		x	y	z
Targets
Familial High risk > Controls (p<0.05, false discovery rate corrected)
Frontal pole	B	16	76	6	3.52	0.00007
Inferior frontal gyrus	L	−58	16	18	3.37	0.0001
Caudate	B	−14	20	10	3.2	0.0003
Inferior temporal gyrus	L	−52	−44	−20	2.94	0.0009
Controls > Familial High Risk (p<0.05, false discovery rate corrected)
Middle frontal gyrus/Precentral gyrus	R	48	8	34	3.0	0.0007
Frontal operculum cortex	L	−46	16	−4	2.94	0.0009
Supplementary motor area	R	18	−16	40	3.02	0.0007
Insula2	L	−34	−18	4	2.94	0.0009
Precentral gyrus	B	10	−26	60	3.29	0.0002
Postcentral gyrus	B	14	−38	54	3.57	0.0001
Superior temporal gyrus2	R	54	−6	−4	3.18	0.0003
Middle temporal gyrus	R	48	−46	8	3.65	0.00004
Precuneus	R	2	−40	46	2.89	0.001
Lateral occipital cortex	B	−20	−74	36	3.36	0.0002
Aversive - Neutral
Familial High Risk > Controls (p<0.05, false discovery rate corrected)
Central opercular cortex	R	50	−2	6	3.01	0.0007
Controls > Familial High Risk (p<0.05, false discovery rate corrected)
Anterior cingulate cortex	L	−6	38	8	2.68	0.002
Precuneus2	L	−10	−54	36	2.7	0.002

B, Bilateral

¹Reported p-values are uncorrected, significant at FDR-corrected value of <0.05

²Clusters showing group differences were outside of task-related network