Table 3.

Areas with Significant Group by Age Interactions

	Hemisphere	MNI coordinates			Max Z-value	Max p-value1	F-value2
		x	y	z
Targets
Controls > Familial High Risk (p<0.05, false discovery rate corrected)
Supramarginal gyrus	R	52	−42	50	2.98	0.0007	11.72
Familial High Risk > Controls (p<0.05, false discovery rate corrected)
Medial frontal cortex	B	−2	44	−12	3.35	0.0002	15.76
Orbitofrontal cortex	L	−30	34	−8	3.3	0.0002	15.16
Anterior cingulate cortex	B	2	42	4	2.8	0.002	10.01
Paracingulate cortex	L	−10	12	46	2.92	0.001	11.07
Insula	R	32	20	4	3.51	0.0001	17.97
Thalamus	B	−8	−14	2	3.14	0.0004	13.39
Temporal pole	R	56	14	−14	2.82	0.001	10.19
Fusiform gyrus	B	32	−66	−8	3.59	0.00005	19.15
Planum temporale	L	−52	−38	16	3.35	0.0002	15.83
Lingual gyrus	B	8	−74	−6	3.19	0.0003	13.9
Lateral occipital cortex	B	24	−68	40	4.13	0.000002	28.7
Supra-/Intracalcarine cortex	B	18	−56	12	4.04	0.000004	26.83
Occipital pole	B	−24	−100	4	3.09	0.0005	12.84
Cerebellum	L	−4	−68	−2	3.37	0.0001	16.12
Aversive > Neutral
Controls > Familial High Risk (p<0.05, false discovery rate corrected)
Frontal pole	L	−12	58	24	3.14	0.0004	13.38
Superior frontal gyrus	R	16	−2	56	3.44	0.0001	16.95
Inferior frontal gyrus	L	−44	18	22	2.66	0.003	8.87
Precentral gyrus	B	16	−2	56	3.44	0.0001	16.95
Postcentral gyrus	L	−50	−28	42	3.12	0.0004	13.13
Supramarginal gyrus	L	−62	−50	32	2.9	0.001	10.91
Intracalcarine cortex	L	−14	−70	12	2.78	0.002	9.86
Familial High Risk > Controls (p<0.05, false discovery rate corrected)
None

B, Bilateral

¹Reported p-values are uncorrected, significant at

FDR-corrected value of <0.05

²F-test for group by age interaction