Fig. 2.

Effects of mephedrone on methamphetamine-induced reductions in striatal DAT. Mice were treated with the indicated doses of mephedrone (MEPH) 30 min prior to each injection of 2.5 (●) or 5.0 mg/kg (■) methamphetamine (METH) and sacrificed 2d later for determination of striatal levels of DAT by immunoblotting (a). Blots were quantified using ImageJ and data are mean ± SEM for 10–12 mice per group (b). *p < 0.01 or ***p < 0.0001 vs control (C) and ^#p < 0.01 or ^##p < 0.001 vs the respective dose of methamphetamine (Tukey's multiple comparison test).