Table 1.
Characteristics of Participants by Amyloid Load Status at Baseline: The 90+ Study
| Characteristic | All Participants (N=13) | Aβ- (N=9) | Aβ+ (N=4) |
|---|---|---|---|
|
Median (Range)
|
|||
| Age at baseline, y | 94.1 (90 - 99) | 94.1 (90 - 99) | 94.4 (93 - 96) |
| Days between baseline visit and PET scan | 42 (8 - 87) | 46 (11 - 87) | 25 (8 - 66) |
| Follow-up, y | 1.5 (0 - 1.6) | 1.5 (0 - 1.6) | 1.4 (1.1 - 1.6) |
| No. of visits | 4 (1 - 4) | 4 (1 - 4) | 3.5 (3 - 4) |
| Average cortical SUVr | 1.1 (0.9 - 2.1) | 1.0 (0.9 - 1.2) | 1.6 (1.3 - 2.1) |
| Median visual score of amyloid load | 1.0 (0 - 4) | 1.0 (0 - 1) | 3.5 (2 - 4) |
| 3MS score at baseline | 93 (80 - 99) | 94 (90 - 97) | 85 (80 - 99) |
| MMSE score at baseline | 28 (24 - 30) | 28 (25 - 30) | 26.5 (24 - 29) |
| CVLT-10 min delay score at baseline | 7 (0 - 9) | 7.5 (5 - 9) | 3.5 (0 - 8) |
| Animal fluency at baseline | 12 (9 - 19) | 12 (9 - 19) | 12 (9 - 18) |
| BNT score at baseline | 14 (13 -15) | 14 (13 -15) | 14 (13 -14) |
|
Number (%)
|
|||
| Gender | |||
| Women | 9 (69) | 7 (78) | 2 (50) |
| Men | 4 (31) | 2 (22) | 2 (50) |
| Education | |||
| ≤High school | 6 (46) | 4 (44) | 2 (50) |
| >High school | 7 (54) | 5 (56) | 2 (50) |
| Cognitive diagnosis at baseline | |||
| Normal | 8 (62) | 7 (78) | 1 (25) |
| CIND | 5 (38) | 2 (22) | 3 (75) |
| Demented during follow-up | 3 (23) | 1 (11) | 2 (50) |
Abbreviations: Aβ- = low amyloid load according to median visual score (0,1); Aβ+ = high amyloid load according to median visual score (2,3,4); SUVr = semiautomated quantitative analysis of the cortical to cerebellar signal ratio; 3MS = Modified Mini-Mental State Exam; MMSE = Mini-Mental State Exam; CVLT = California Verbal Learning Test; BNT = Boston Naming Test; CIND = Cognitive impairment no dementia