. Author manuscript; available in PMC: 2014 Mar 1.

Published in final edited form as: Alzheimers Dement. 2012 Nov 16;9(2):199–203. doi: 10.1016/j.jalz.2012.06.005

Table 2.

Average Yearly Rate of Change in Cognitive Tests by Amyloid Load Status at Baseline

	Slopes calculated from averaging individual slopes						Slopes calculated from random effects models
	Aβ-		Aβ+		t-test	Wilcoxon rank test	Aβ-	Aβ+
						Wilcoxon rank test
Cognitive Test	N	Slope (SE)	N	Slope (SE)	p-value^a	p-value^a	Slope	Slope	p-value^b

3MS	8	-1.26 (1.20)	4	-12.35 (3.99)	0.006	0.04	-1.56	-12.63	<0.001
MMSE	8	0.38 (0.54)	4	-4.99 (1.40)	0.001	0.03	0.24	-4.96	<0.001
CVLT	7	-0.17 (0.62)	4	-1.82 (1.01)	0.17	0.25	-0.32	-1.04	0.45
Animal Fluency	8	0.79 (0.77)	4	-2.59 (1.85)	0.07	0.10	0.25	-2.29	0.05
BNT	6	0.38 (0.38)	3	-1.45 (0.41)	0.02	0.06	0.17	-0.95	0.07

Abbreviations: Aβ - = low amyloid load according to median visual score (0,1) ; Aβ + = high amyloid load according to median visual score (2,3,4); 3MSE = Modified Mini-Mental State Examination; MMSE = Mini-Mental State Examination; CVLT = California Verbal learning Test 10-minute delay; BNT = Boston Naming Test

t-test and Wilcoxon rank test comparing average slopes for Aβ- and Aβ+ groups

p-value for the interaction between years from baseline and Aβ group. A significant interaction indicates a difference in the rate of cognitive decline in the Aβ– and Aβ+ groups