Table 1.

Sleep % in OxR2-siRNA and ctrl-siRNA treated rats.

	OxR2-siRNA (N=7)			Ctrl-siRNA (N=7)
Period (12 hr)	Mean (± SEM) % time spent in			Mean (± SEM) % time spent in
	Wakefulness	NREMS	REMS	Wakefulness	NREMS	REMS
Dark 0	68.7±1.4	27.2±1.0	4.0±0.5	62.3±2.6	33.2+2.2	4.5+0.5
Dark 1	64.6±2.6	29.4±2.2	6.0±0.9 *	61.7±2.6	32.9+2.2	5.0+0.5
Dark 2	62.3±2.6	25.9±2.0	6.1±0.7 *	62.6±3.6	32.2+2.9	4.9+0.7
Dark 3	65.2±2.3	29.5±1.5	5.2±1.0
Dark 4	66.9±3.4	28.8±2.7	4.3±0.8
Light0	30.7±2.8	60.2±2.5	9.2±0.7	29.8±3.3	62.0±3.7	8.2±0.5
Light 1	28.2±2.1	60.3±1.7	11.6±0.8	34.1±3.8	58.2±3.9	7.4±0.9
Light 2	29.1 ±1.2	60.0±1.0	10.9±1.2	32.6±2.5	59.1±2.8	7.9±0.7
Light 3	30.4±1.4	60.8±1.1	8.8±0.4
Light 4	30.8±1.3	60.9±0.6	8.3±0.6

Percentage of REM sleep increases on dark periods 1 and 2 in animals treated with OxR2 siRNA. Dark= 7 PM to 7 AM; Light = 7 AM to 7 PM; Dark 0 or Light 0 = Pre-injection dark or light period. Dark 1-4 = Post-injection dark periods; Light 1-4 = post-injection light periods;

^*= P<0.05 versus Dark 0 (Dunnett’s test).