Table 2.

REM sleep parameters during the dark period in OxR2-siRNA injected animals.

		REM sleep
siRNA	Period	Number	Duration	Latency	R-R Cycle
OxR2	Dark 0	23.0±2.7	1.2±0.1	6.6±0.7	29.2±3.0
	Dark 1	27.3±2.7	1.5±0.1 *	8.5±1.2	24.2±2.7
	Dark 2	30.1±3.2	1.4±0.1	6.8±0.6	22.0±2.0
	Light0	39.1±3.4	1.7±0.1	5.6±0.6	18.3±1.5
	Light1	45.0±3.7	1.8±0.1	5.8±0.5	16.1 ±1.4
	Light2	42.6±5.3	1.8±0.1	6.3±0.7	18.3±2.7

Compared to Dark 0, the length of REM sleep episodes increased during Dark 1. Dark= 7 PM to 7 AM; Dark 0 = Pre-injection dark period. Dark 1-2 = Post-injection dark periods; Duration and latency and REMS-REMS cycle duration (R-R cycle) are all expressed as minutes. REM sleep latency is defined as the time between the beginning of a REM sleep episode and the preceding wakefulness episode. R-R cycle is defined as from the beginning of a REM sleep episode to the beginning of the next REM sleep episode. All data are mean ± SEM.

^*= P<0.05 versus Dark 0 (Dunnett’s test).