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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Biochem Pharmacol. 2013 Feb 8;85(8):1195–1202. doi: 10.1016/j.bcp.2013.01.031

Fig. 4. Glucuronidation of PTI by human liver microsomes.

Fig. 4

A: Time course of the levels of PTI and its metabolites in PTI-treated HLMs in the presence of UDP-glucuronic acid. B: Comparison of glucuronide formation from PTI versus IND in HLMs treated with the esterase inhibitor DFP. HLMs were treated with PTI (dotted line) or IND (solid line) in the presence of DFP for 2 h, and the metabolite levels were determined by HPLC. The respective chromatograms are shown. The off-scale peak values of IND and PTI were 0.41 and 0.25 units, respectively.