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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Biochem Pharmacol. 2013 Feb 8;85(8):1195–1202. doi: 10.1016/j.bcp.2013.01.031

Fig. 7. Overall metabolic pathways of PTI in vitro and in vivo.

Fig. 7

PTI undergoes hydrolysis, hydroxylation, O-demethylation and N-debenzoylation reactions to generate IND, hydroxy-PTI, demethyl-PTI and debenzoyl-PTI, respectively. The resulting IND can be transformed to demethyl-IND and debenzoyl-IND, which, in turn, can be glucuronidated. Demethyl-IND can also be sulfated. SULTs, sulfotransferases.