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The stability (t1/2 and CLint) of PTI in mouse, rat and human microsomes from various tissues.
| t1/2 min |
CLint ml/min/g |
|
|---|---|---|
| Mouse liver microsomes | 8.0 | 172.4 |
| Rat liver microsomes | 37.6 | 36.9 |
| Human liver microsomes | 13.9 | 100.0 |
| Human intestine microsomes | 13.2 | 210.0 |
| Human kidney microsomes | 77.3 | 35.9 |
| Human lung microsomes | 348.0 | 8.0 |
