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Kinetic parameters for the hydroxylation and O-demethylation reactions of PTI by human recombinant CYPs.
| Hydroxylation of PTI | O-demethylation of PTI | |||||
|---|---|---|---|---|---|---|
| Km | Vmax | Vmax/Km | Km | Vmax | Vmax/Km | |
| µM |
pmol/min/ pmol CYP |
µl/min/pmol CYP |
µM |
pmol/min/ pmol CYP |
µl/min/pmol CYP |
|
| CYP1A2 | ND | ND | ||||
| CYP2C9 | ND | ND | ||||
| CYP2C19 | ND | ND | ||||
| CYP2D6 | ND | 4.0 | 70.0 | 17.5 | ||
| CYP3A4 | 2.5 | 27.5 | 27.5 | 44.5 | 1.5 | 0.03 |
ND, Not detectable
