Table 3.

Association between 10-year mean daily antioxidant supplement use and incident pancreatic cancer, VITAL cohort from 2000–2008

Antioxidant	Intake level	No. of subjects	No. of cases	Crude HR	P-trend	Adjusted HR*	P-trend
Vitamin C (mg)	Non-user	20651	53	1.00		1.00
	2.57– 148.57	28080	67	0.93(0.65– 1.34)		0.93(0.65– 1.34)
	149.00– 1750.00	28083	59	0.82(0.56– 1.18)	0.53	0.82(0.56– 1.19)	0.44
Vitamin E (mg)	Non-user	20194	53	1.00		1.00
	1.29– 100.86	28329	67	0.90(0.63– 1.29)		0.92(0.64– 1.32)
	101.00– 1000.00	28328	64	0.86(0.60– 1.24)	0.80	0.80(0.55– 1.17)	0.37
Multi-Vitamin (pills)	Non-user	26732	70	1.00		1.00
	0.04– 0.70	23934	54	0.86(0.60– 1.23)		0.95(0.66– 1.36)
	0.79– 1.00	26770	60	0.86(0.61– 1.21)	0.34	0.81(0.57– 1.15)	0.14

^*Models were adjusted for age, gender, ethnicity, education, body mass index, physical activity, cigarette smoking status, total alcohol consumption, family history of pancreatic cancer and history of diabetes.