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Comparative liver histology of lamprey adult females, adult males, and larvae. H&E staining demonstrates that bile duct epithelium is absent in adult male (A) and female (B) but present in larval (C) lamprey. Note the absence of inflammation, cell injury and fibrosis. Immunohistochemistry (C219 monoclonal antibody) staining Mdr1-like protein in bile canaliculi from larval (F) but not adult male (D) or female (E) livers.
