Table 1. Main Characteristics and Results of the Eligible Studies.

First Author	Year	Country of Origin	Recruitment Time	N	Male%	Age	Stage	Location	Preop treatment	Follow-up (Months)	COX-2 expression (%)
Miladi-Abdennadher [35]	2012	Tunisia	NS	35	NS	NS	I∼IV	Colorectal	NS	NS	65.7
Al-Maghrabi [36]	2012	Saudi Arabia	2005∼2009	94	51.1	59	I∼IV	Colon	NS	NS	56.4
Yoshinaga [31]	2011	Japan	2003∼2007	52	52	71.1	I∼IV	Colorectal	NS	NS	63.5
Pancione [37]	2009	Italy	1999∼2009	72	61.1	70.5	I∼IV	Colon	None	56	54.2
Inafuku [38]	2009	Japan	1996∼2005	109	55	NS	II	Colon	NS	NS	56
Debucquoy [39]	2009	Belgium	1996∼2003	99	64.6	63	NS	Rectal	RT±CT	42.4	80.8
Ogino [40]	2009	USA	1976∼2002	662	43	66.5	I∼IV	Colon	NS	NS	82.8
Lim [41]	2008	Korea	1992∼2001	231	48.5	61.2	I∼III	Colorectal	None	55.8	42.4
Chen [33]	2008	China	1999∼2001	96	60	54.8	I∼IV	Colorectal	None	NS	53.3
de Heer [25]	2007	Netherlands	1996∼1999	510	NS	NS	I∼III	Rectal	RT	NS	28
de Heer [25]	2007	Netherlands	1996∼1999	528	NS	NS	I∼III	Rectal	None	NS	33
Giralt [34]	2006	Spain	1994∼2001	74	66.7	64.8	Locally advanced	Rectal	RT±CT	53	51.4
Yamac [42]	2005	Turkey	1989∼1999	83	62.6	55	II∼IV	Colorectal	NS	37	62.6
Fux [43]	2005	Germany	1987∼1997	747	47.9	70.3	I∼IV	Colorectal	None	48.7	84.6
Zhan [44]	2004	China	1992∼2001	44	63.2	NS	I∼IV	Colorectal	NS	42	72.7
Soumaoro [45]	2004	Japan	1986∼1996	288	63.5	61	I∼IV	Colorectal	None	63	70.8
Wu [46]	2003	China	1993∼2001	139	50.4	59	I∼IV	Colorectal	NS	55	84.9
Buecher [47]	2003	France	1996∼1997	61	55.7	70.2	I∼II	Colorectal	NS	55.9	59
Zhang [48]	2002	Sweden	1972∼1996	112	NS	NS	I∼IV	Colorectal	NS	51.6	72.3
Yamauchi [49]	2002	Japan	1990∼1993	232	60.3	63	I∼III	Colorectal	NS	68	71.6
Joo [50]	2002	Korea	1995	60	58.3	60.7	I∼IV	Colorectal	None	72	70
Tomozawa [19]	2000	Japan	1990∼1994	63	60.3	NS	I∼III	Colorectal	NS	60	20.6
Masunaga [51]	2000	Japan	1990∼1999	100	59	NS	I∼IV	Colorectal	None	54	72
Sheehan [24]	1999	Ireland	1988∼1991	76	50	66.5	I∼IV	Colorectal	NS	32.4	81.6