Figure 1.

Infection of cynomolgus macaques with simian immunodeficiency virus–human immunodeficiency virus 89.6P (SHIV_89.6P) is associated with elevated right atrial, right ventricular, and pulmonary arterial pressures (Mann-Whitney test, P = 0.001, 0.042, and 0.001, respectively), but not pulmonary capillary wedge pressure (Mann-Whitney test, P = 0.274). Right heart catheterizations were performed in 19 macaques, at approximately 20 months after SHIV infection, and compared with four uninfected control animals.