Figure 4.
Hemodynamic evaluation of simian immunodeficiency virus (SIV)–infected rhesus macaques (Monkey numbers R58, R67, R73, R80, R85; see Table E1 for infection details). (A) Pulmonary artery systolic pressure is significantly elevated in rhesus macaques (RM) by 3 months post-SIV infection (PI) compared with baseline, as determined by Doppler echocardiography (two-way ANOVA, P = 0.023). Right heart catheterizations were performed in four rhesus macaques at baseline (before infection) and approximately 8 months after infection (PI). (B) Infection with SIVΔB670 is associated with elevated right atrial and pulmonary artery pressure and pulmonary artery systolic pressure (paired t test, P = 0.006, 0.032, and 0.038, respectively), but not pulmonary capillary wedge pressure (P = 0.215). (C) No significant difference was evident in systemic blood pressure before and after SIV infection (two-way ANOVA, P = 0.903). mos, months.