Figure 5.
Quantitative evidence of vascular pruning on computed tomography scans. Quantitative analysis of cross-sectional area (CSA) of vessels was performed, and indicated significantly fewer small vessels (CSA < 5 mm2) in SHIV-infected macaques (n = 19) than in control animals (n = 10; t test, P = 0.041). No significant difference was evident in vessels measuring 5–10 mm2 (t test, P = 0.450). %CSA, percentage of cross-sectional area; CSA<5 mm2, vessels with cross-sectional area < 5 mm2; CSA5–10 mm2, vessels with a cross-sectional area of 5–10 mm2. *P = 0.04.