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. Author manuscript; available in PMC: 2014 Mar 19.
Published in final edited form as: Biochemistry. 2013 Mar 4;52(11):1913–1926. doi: 10.1021/bi301313b

FIGURE 1.

FIGURE 1

pH-dependent aggregation of native and oxidized TTRs. WT (a, c) and V122I TTR (b, d) and their oxidized isoforms (oxi-TTRs and car-TTRs) were incubated for 7 days at the designated pH at 37 °C. The extent of aggregation was measured by turbidity at 400 nm (a, b) and percentage of insoluble protein with respect to initial protein content (c, d). Native TTR (solid line, squares), oxi-TTR (broken line, circles), car-TTR (dotted line, triangles). WT TTR and its isoforms are represented by solid symbols; V122I TTR and its oxidized isoforms are represented by open symbols. Data shown for one representative experiment performed in triplicate (mean ± SD).