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Kinetics of fibril formation of monomeric M-TTR and its oxidized isoforms. Aggregation of native M-TTR (solid line, squares), oxi-M-TTR (broken line, circles), car-M-TTR (dotted line, triangles) was induced by incubation at pH 4.4 at 37 °C without agitation. Percentage of insoluble TTR was measured over time. Data shown for one representative experiment performed in triplicate (mean ± SD).
