Table 2.
In utero exposures and the odds of an endometriosis diagnosis by cohort, The ENDO Study.
| Operative Cohort (n=473) | Population Cohort (n=127) | |||
|---|---|---|---|---|
| In Utero Exposures | Unadjusted OR (95% CI) | Adjusted OR1 (95% CI) | Unadjusted OR (95% CI) | Adjusted OR1 (95% CI) |
| Maternal Behavior | ||||
| Vitamins | 1.29 (0.87, 1.91) | 1.27 (0.85, 1.91) | 0.62 (0.18, 2.10) | 0.60 (0.16, 2.15) |
| Caffeine | 0.82 (0.54, 1.25) | 0.99 (0.64, 1.54) | 0.86 (0.22, 3.32) | 0.76 (0.19, 3.03) |
| Cigarettes | 1.15 (0.61, 2.16) | 1.16 (0.61, 2.24) | -- | -- |
| Alcohol | 0.76 (0.33, 1.75) | 0.82 (0.35, 1.94) | -- | -- |
| Paternal Behavior | ||||
| Cigarettes | 0.72 (0.44, 1.18) | 0.72 (0.43, 1.19) | 3.41 (0.82, 14.3) | 3.43 (0.75, 15.7) |
| Index Woman | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) |
|---|---|---|---|---|
| Preterm | 1.00 (0.50, 1.99) | 0.98 (0.47, 2.03) | -- | -- |
| Low Birth Weight2 | 1.09 (0.92, 1.30) | 1.10 (0.92, 1.32) | 0.80 (0.50, 1.28) | 0.81 (0.50, 1.32) |
NOTE: In utero exposures were simultaneously included in model.
1
Model adjusted for clinical site (California/Utah), currently smoking (yes/no), age at menarche (years) and BMI (weight in kg/height in m2).
2
As lower birth is associated with increased risk of endometriosis in previous studies, birth weight entered the model so that the estimated OR/AOR confers the effect of every pound less in weight.