. Author manuscript; available in PMC: 2014 Mar 27.

Published in final edited form as: Transplantation. 2013 Mar 27;95(6):821–827. doi: 10.1097/TP.0b013e31827e6ad9

Table 2.

AUC_0–infinity and AUC_metabolite/AUC_{CsA(0-infinity)} of Cyclosporine A and its metabolites for study participants stratified by predicted CYP3A5 phenotype.

	CYP3A5 Expressors (N=12)	CYP3A5 Nonexpressors (N=12)	P value
AUC_0–infinity
CsA	6098 ± 1509	5670 ± 1603	0.51
AM1	4711 ± 1509	4900 ± 2188	0.81
AM9	3186 ± 766	2801 ± 712	0.22
AM4N	418 ± 118	456 ± 94	0.39
AM1c	197 ± 94	185 ± 79	0.74
AM19	1360 ± 602	923 ± 343	0.040
AM1c9	162 ± 62	107± 29	0.011

AUC_m/AUC_CsA
AM1	0.76 ± 0.12	0.84 ± 0.23	0.29
AM9	0.52 ± 0.06	0.49 ± 0.08	0.35
AM4N	0.07 ± 0.02	0.08 ± 0.02	0.16
AM1c	0.03 ± 0.01	0.03 ± 0.01	0.82
AM19	0.21 ± 0.05	0.16 ± 0.04	0.016
AM1c9	0.03 ± 0.01	0.02 ± 0.01	0.025

Data are presented as mean ± SD. AUC, area under the concentration–time curve, expressed in units of ng hr/mL.