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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Biochem Pharmacol. 2013 Feb 5;85(8):1066–1076. doi: 10.1016/j.bcp.2013.01.026

Figure 3.

Figure 3

Topical treatment of mice with silymarin improves the functionality of DCs from UVB-irradiated wild-type mice and enhances the proliferation of CD4+ T cells, but not in XPAKO mice. CD4+ T cells isolated from the spleens of naïve mice (wild-type) were labeled with CFSE and co-cultured with CD11c+ cells (DCs) isolated from lymph nodes of the different treatment groups of wild-type and XPA-KO mice in the presence of anti-CD3e (5.0 μg/ml). After 4 days of co-culture, cells were harvested and analyzed for their proliferation index using FACS. Representative histograms from one experiment are shown from a total of two independent experiments. Numerical values in different treatment groups indicate percentage of proliferating CD4+ T cells.