Table 1.

Silymarin enhances the production of IFNγ and IL-12 by DCs obtained from UVB-irradiated wild-type mice but not DCs obtained from XPA-KO mice.

Cytokines	Wild-type			XPA-KO
	Control	UVB	SLM +UVB	Control	UVB	SLM+ UVB
IFNγ	3989	1765¶	3010*	2508	1764¶	1883
IL-12	57	12¶	46*	21	5¶	7
IL-10	288	394**	300†	203	339**	371

Wild-type and XPA-KO mice that were treated or not-treated with silymarin were exposed to UVB irradiation three times on consecutive days. Mice were sacrificed 24 h after the last UVB exposure and DCs (CD11c⁺ cells) were positively selected from the lymph nodes. DCs were stimulated with LPS (5μg/mL) for 48 h. After incubation, cells were harvested and supernatants collected. The concentrations of cytokines in the cell supernatants were estimated by ELISA. The data are presented as the mean in terms of pg/2 million cells, n=5.

^¶Significant decrease versus non-UVB control, P<.001

^*significant increase versus UVB alone, P<0.001.

^†Significant decrease versus UVB alone, P<0.05.

^**Significant increase versus non-UVB control P<0.01.

SLM= silymarin.