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. 2013 Mar 20;8(3):e59667. doi: 10.1371/journal.pone.0059667

Figure 6. Regulation of activin-induced genes by miR-181a.

Figure 6

(A, B, and C) Mouse granulosa cells (mGC) were infected with 50 MOI Ad-miR-181a or Ad-LacZ for 24 h, followed by 50 ng/ml activin A stimulation for another 24 h. CYP19A1, P450scc, and ESR1 levels were measured by qRT-PCR. Bars labeled with different letters indicate statistically significant differences (p<0.05). (D, E, and F) qRT-PCR analysis of CYP19A1, P450scc, and ESR1 expression in mGC transfected with 100 nM miR-181a inhibitor for 24 h. *p<0.05, compared with controls.