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Angiotensin receptor blockade with neutral endopeptidase inhibition effects: decreased blood pressure as a result of the direct antihypertrophic, anti-fibrotic, endothelial, and renal-enhancing actions mediated by increased biological activities of the natriuretic peptides and by increased angiotensin type 2 receptor binding (adapted from Ruilope et al.,101 Copyright 2010, with permission from Elsevier).
