Table 1.

Proposed definition of kidney disease in cirrhosis⁶⁰

Diagnosis	Definition
Acute kidney injury	Rise in serum creatinine of ≥50% from baseline or a rise in serum creatinine of ≥26.4 µmol/l (≥0.3 mg/dl) in <48 h
	HRS type 1 is a specific form of acute kidney injury
Chronic kidney disease	Glomerular filtration rate of <60 ml/min for >3 months calculated using MDRD6 formula
	HRS type 2 is a specific form of chronic kidney disease
Acute-on-chronic kidney disease	Rise in serum creatinine of ≥50% from baseline or a rise in serum creatinine of ≥26.4 µmol/l (≥0.3 mg/dl) in <48 h in a patient with cirrhosis whose glomerular filtration rate is <60 ml/min for >3 months calculated using MDRD6 formula

HRS, hepatorenal syndrome; MDRD, Modification of Diet in Renal Disease.