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Comparison of key events in the 90-day MOA study and the NTP 2-year bioassay. The term “diffuse hyperplasia” includes both villous toxicity and crypt hyperplasia. Together, these studies establish that villous cytotoxicity is an antecedent to tumor formation in the mouse small intestine. This illustration is patterned after a generalized scheme in Meek & Klaunig (2010).
