Table 10.
Key event | Mice | Rats | Humans |
---|---|---|---|
Intestinal absorption | Yes† | Yes† | Yes |
Villous cytotoxicity | Yes | Yes, at higher concentrations‡ | No data; unlikely at environmentally-relevant doses |
Crypt proliferation | Yes | Yes, at higher concentrations‡ | No data; unlikely at environmentally-relevant doses |
Crypt cell mutagenesis | Yes | No data, but possible at higher concentrations | No data; unlikely at environmentally-relevant doses |
Tumorigenesis | Yes | No, but possible at higher concentrations | No data; unlikely at environmentally-relevant doses |