Table 10.

Concordance table for human relevance.

Key event	Mice	Rats	Humans
Intestinal absorption	Yes†	Yes†	Yes
Villous cytotoxicity	Yes	Yes, at higher concentrations‡	No data; unlikely at environmentally-relevant doses
Crypt proliferation	Yes	Yes, at higher concentrations‡	No data; unlikely at environmentally-relevant doses
Crypt cell mutagenesis	Yes	No data, but possible at higher concentrations	No data; unlikely at environmentally-relevant doses
Tumorigenesis	Yes	No, but possible at higher concentrations	No data; unlikely at environmentally-relevant doses

†Measured in Thompson et al. (2011b, 2012c).

‡Observed in Thompson et al. (2012c) but not in NTP (2008a) due to higher water intake in the former.