Table 5.
Total number of aberrant nuclei in fully intact duodenal crypts.
| Dose | Mitotic index (%)† | Apoptotic index (%)‡ | Karyorrhectic nuclei | Micronuclei | Cells evaluated¶ |
|---|---|---|---|---|---|
| 0 | 1.43 ± 1.17 | 0.47 ± 0.22 | 0 | 0 | 1921 |
| 0.3 | 2.28 ± 1.07 | 1 ± 0.47 | 4 | 0 | 1707 |
| 4 | 2.36 ± 0.684 | 0.5 ± 0.41 | 0 | 0 | 1825 |
| 14 | 3.08 ± 0.46 | 0.7 ± 0.32 | 0 | 0 | 1420§ |
| 60 | 2.43 ± 0.76 | 0.5 ± 0.36 | 0 | 0 | 2386 |
| 170 | 2.72 ± 0.97 | 0.84 ± 0.96 | 0 | 0 | 2746 |
| 520 | 2.11 ± 1.09 | 0.67 ± 0.33 | 0 | 0 | 3194 |
mg/l SDD. There were no statistically significant differences between treatment and control groups (ANOVA followed by Dunnett’s test).
†MI = total mitotic nuclei ÷ total nuclei (in 10 crypts). Data are Mean +/− SD
‡AI = total apoptotic nuclei ÷ total nuclei (in 10 crypts) Data are Mean +/− SD.
¶Total number of cells evaluated (10 crypts per animal; n = 5 animals per treatment group).
§n = 4 animals.